Protein nano-machines are large protein complexes that can perform a mechanical movement upon receiving specific stimuli. In bacteria in particular, these play essential roles in cell organization, motility and interaction with their surroundings. My research focuses on the characterization of these complexes at the atomic level, using a range of stuctural and biophysical methods (cryo-EM, X-ray crystallography, NMR, modeling etc...).
The goal of my research is to understand the molecular mechanism of action of these nano-machines, and their interaction with other cellular components. Ultimately, I hope to exploit this knowledge for the development of new antibiotics and drug delivery systems.
22/12/16 - Our cryo-EM structure of the T3SS basal body has been published in the journal Nature: goo.gl/9grdaT